Cargando…

Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties

Novel series of amidines were synthesized via the interaction between alicyclic amines, cyclic ketones, and a highly electrophilic 4-azidoquinolin-2(1H)-ones without any catalyst or additive. All the obtained products were elucidated based on NMR spectroscopy, mass spectrometry, and elemental analys...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Sheref, Essmat M., Tawfeek, Hendawy N., Hassan, Alaa A., Bräse, S., Elbastawesy, Mohammed A. I., Gomaa, Hesham A. M., Mostafa, Yaser A., Youssif, Bahaa G. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716094/ https://www.ncbi.nlm.nih.gov/pubmed/36465858 http://dx.doi.org/10.3389/fchem.2022.1039176

Ejemplares similares

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors
por: El-Sheref, Essmat M., et al.
Publicado: (2023)

Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents
por: El-Sheref, Essmat M., et al.
Publicado: (2021)

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action
por: El-Sheref, Essmat M., et al.
Publicado: (2022)

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF(V600E): Design, Synthesis, and Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF(V600E) Inhibitory Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

Acyl Amidines by Pd-Catalyzed Aminocarbonylation: One-Pot Cyclizations and (11)C Labeling
por: Rydfjord, Jonas, et al.
Publicado: (2022)

Chemistry of Substituted Thiazinanes and Their Derivatives
por: Hassan, Alaa A., et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

Amidine- and Amidoxime-Substituted Heterocycles: Synthesis, Antiproliferative Evaluations and DNA Binding
por: Maračić, Silvija, et al.
Publicado: (2021)

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity
por: Maghraby, Mohamed T-E, et al.
Publicado: (2023)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAF(V600E)
por: Alshammari, Mohammed B., et al.
Publicado: (2022)

Amidine Dications as Superelectrophiles
por: Corr, Michael J., et al.
Publicado: (2009)

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Copper-Catalyzed One-Pot Synthesis of N-Sulfonyl Amidines from Sulfonyl Hydrazine, Terminal Alkynes and Sulfonyl Azides
por: Zhao, Yu, et al.
Publicado: (2021)

Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF(V600E)
por: El-Kalyoubi, Samar A., et al.
Publicado: (2023)

Synthesis of Calcium(II) Amidinate Precursors for Atomic Layer Deposition through a Redox Reaction between Calcium and Amidines
por: Kim, Sang Bok, et al.
Publicado: (2016)

Aluminum Amidinates: Insights into Alkyne Hydroboration
por: Hobson, Katie, et al.
Publicado: (2021)

Zwitterionic amidinates as effective ligands for platinum nanoparticle hydrogenation catalysts
por: Martínez-Prieto, L. M., et al.
Publicado: (2017)

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFR(T790M)/BRAF(V600E) Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Amidine Dications: Isolation and [Fe]-Hydrogenase-Related Hydrogenation
por: Corr, Michael J., et al.
Publicado: (2009)

Aminolysis of an N-Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia
por: Biswas, Debanjan, et al.
Publicado: (2014)

Crystal and molecular structures of two silver(I) amidinates, including an unexpected co-crystal with a lithium amidinate
por: Wang, Sida, et al.
Publicado: (2016)

Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV(600E)
por: Hagar, Fatma Fouad, et al.
Publicado: (2023)

Transition metal- and catalyst-free one-pot green method for the synthesis of N-sulfonyl amidines via direct reaction of sulfonyl azides with amines
por: Kaboudin, Babak, et al.
Publicado: (2020)

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2
por: Tantawy, Ahmed H., et al.
Publicado: (2021)

Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids
por: El-Sheref, Essmat M., et al.
Publicado: (2020)

From cyclic amines and acetonitrile to amidine zinc(ii) complexes
por: Podjed, Nina, et al.
Publicado: (2020)

Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
por: Zaki, Islam, et al.
Publicado: (2022)

T91. DEVELOPMENT OF NOVEL BIS-AMIDINES FOR THE TREATMENT OF TOXOPLASMOSIS
por: Jones-Brando, Lorraine, et al.
Publicado: (2018)

Enantiomerically Pure Tetravalent Neptunium Amidinates: Synthesis and Characterization
por: Fichter, Sebastian, et al.
Publicado: (2020)

Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis
por: Vastl, Julian, et al.
Publicado: (2016)

Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
por: Adiyala, Praveen Reddy, et al.
Publicado: (2014)

Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism
por: Abourehab, Mohammed A. S., et al.
Publicado: (2021)

Palladium-Mediated Synthesis of [Carbonyl-(11)C]acyl Amidines from Aryl Iodides and Aryl Bromides and Their One-Pot Cyclization to (11)C-Labeled Oxadiazoles
por: Rydfjord, Jonas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ls0gri7p55m36apea93rn4uhve