Cargando…

Somatic mutations of activating signalling, transcription factor, and tumour suppressor are a precondition for leukaemia transformation in myelodysplastic syndromes

The transformation biology of secondary acute myeloid leukaemia (AML) from myelodysplastic syndromes (MDSs) is still not fully understood. We performed paired self‐controlled sequencing, including targeted, whole exome, and single‐cell RNA sequencing, in a cohort of MDS patients to search for AML tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Feng, Wu, Lin‐Yun, Guo, Juan, He, Qi, Zhang, Zheng, Li, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716205/ https://www.ncbi.nlm.nih.gov/pubmed/36380727 http://dx.doi.org/10.1111/jcmm.17613

Ejemplares similares

Transformation of myelodysplastic syndrome to mixed phenotype acute leukaemia
por: Do, Louis, et al.
Publicado: (2020)

Somatic mutations predict outcomes of hypomethylating therapy in patients with myelodysplastic syndrome
por: Jung, Seung-Hyun, et al.
Publicado: (2016)

Serial monitoring of circulating tumour DNA on clinical outcome in myelodysplastic syndromes and acute myeloid leukaemia
por: Zhou, Xinping, et al.
Publicado: (2023)

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome
por: Schieber, Michael, et al.
Publicado: (2020)

Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes
por: Zeng, Xiangzong, et al.
Publicado: (2021)

PB1916: SOMATIC MUTATIONS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME IN RUSSIAN PATIENTS
por: Kohno, A., et al.
Publicado: (2022)

Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations
por: Aslan, Derya, et al.
Publicado: (2016)

An Association Between Hypoplastic Myelodysplastic Syndrome and T-Prolymphocytic Leukaemia
por: Arathi, C A, et al.
Publicado: (2011)

Decitabine/cedazuridine for chronic myelomonocytic leukaemia, myelodysplastic syndromes
Publicado: (2022)

Association of Somatic Gene Mutations with Risk of Transformation into Acute Myeloid Leukemia in Patients with Myelodysplastic Syndrome: A Systematic Review and Meta-Analysis
por: Sutandyo, Noorwati, et al.
Publicado: (2022)

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
por: Zuckermann, Marc, et al.
Publicado: (2015)

A Carotid Body Tumour Mimicking Richter’s Transformation of Chronic Lymphocytic Leukaemia
por: Qamar, Younus, et al.
Publicado: (2022)

Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia
por: Hawkins, Edwin D., et al.
Publicado: (2014)

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
por: Hesson, Luke B, et al.
Publicado: (2009)

Atypical chronic myeloid leukaemia – a rare subtype of myelodysplastic/myeloproliferative neoplasm
por: Drozd-Sokołowska, Joanna E., et al.
Publicado: (2018)

Identification and analysis of mutational hotspots in oncogenes and tumour suppressors
por: Baeissa, Hanadi, et al.
Publicado: (2017)

Spanish Guidelines for the use of targeted deep sequencing in myelodysplastic syndromes and chronic myelomonocytic leukaemia
por: Palomo, Laura, et al.
Publicado: (2019)

Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
por: Shi, Y. F., et al.
Publicado: (1996)

E2F4 functions as a tumour suppressor in acute myeloid leukaemia via inhibition of the MAPK signalling pathway by binding to EZH2
por: Feng, Yubin, et al.
Publicado: (2020)

PB2013: THE FREQUENCY, EVOLUTION AND SIGNIFICANCE OF GENE MUTATION IN MYELODYSPLASTIC SYNDROMES WITH NORMAL KARYOTYPE
por: Xu, Feng, et al.
Publicado: (2023)

Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer
por: Boström, Martin, et al.
Publicado: (2022)

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia
por: Perrotti, D, et al.
Publicado: (2006)

Transcript- and tissue-specific imprinting of a tumour suppressor gene
por: Schulz, Reiner, et al.
Publicado: (2009)

Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia
por: Bailey, G. D., et al.
Publicado: (2020)

Somatic mutations as markers of outcome after azacitidine and allogeneic stem cell transplantation in higher-risk myelodysplastic syndromes
por: Falconi, Giulia, et al.
Publicado: (2018)

Impact of somatic mutations on response to lenalidomide in lower-risk non-del(5q) myelodysplastic syndromes patients
por: Santini, Valeria, et al.
Publicado: (2020)

Somatic glypican 3 (GPC3) mutations in Wilms' tumour
por: White, G R M, et al.
Publicado: (2002)

Somatic mutations of KIT in familial testicular germ cell tumours
por: Rapley, E A, et al.
Publicado: (2004)

Germline mutations and somatic inactivation of TRIM28 in Wilms tumour
por: Halliday, Benjamin J., et al.
Publicado: (2018)

Thyroid Tumours,Lymphomas, Granulocytic Leukaemia
por: Duthie, M. B., et al.
Publicado: (1973)

Case of Lymphatic Leukæmia, with Tumour in the Mediastinum
por: Gowans, James
Publicado: (1876)

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
por: Li, Yilong, et al.
Publicado: (2014)

miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
por: Li, Zejuan, et al.
Publicado: (2012)

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia
por: Mueller, B U, et al.
Publicado: (2006)

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia
por: Mueller, B U, et al.
Publicado: (2006)

RNA polymerase III transcription is repressed in response to the tumour suppressor ARF
por: Morton, Jennifer P., et al.
Publicado: (2007)

Immunoglobulin heavy variable somatic hyper mutation status in chronic lymphocytic leukaemia: on the threshold of a new era?
por: Langerak, Anton W., et al.
Publicado: (2020)

Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations
por: Hatakeyama, Keiichi, et al.
Publicado: (2018)

Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping
por: Sanjaya, Prima, et al.
Publicado: (2023)

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis
por: Morra, Francesco, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9u2o8ukfmk4kbm24n2cfbno00h