An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

PURPOSE: Factor H (FH, encoded by CFH) prevents activation of the complement system's alternative pathway (AP) on host tissues. FH impedes C3 convertase (C3bBb) formation, accelerates C3bBb decay, and is a cofactor for factor I (FI)–catalyzed C3b cleavage. Numerous CFH variants are associated w...

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Detalles Bibliográficos
Autores principales: Biggs, Robyn M., Makou, Elisavet, Lauder, Scott, Herbert, Andrew P., Barlow, Paul N., Katti, Suresh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716232/
https://www.ncbi.nlm.nih.gov/pubmed/36445700
http://dx.doi.org/10.1167/iovs.63.12.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716232/
https://www.ncbi.nlm.nih.gov/pubmed/36445700
http://dx.doi.org/10.1167/iovs.63.12.30

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