The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose

The TP53 gene is mutated in 80% of triple-negative breast cancers. Cells that harbor the hot-spot p53 gene mutation R273H produce an oncogenic mutant p53 (mtp53) that enhances cell proliferative and metastatic properties. The enhanced activities of mtp53 are collectively referred to as gain-of-funct...

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Detalles Bibliográficos
Autores principales: Lundine, Devon, Annor, George K., Chavez, Valery, Maimos, Styliana, Syed, Zafar, Jiang, Shuhong, Ellison, Viola, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Signal Transduction and Functional Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716242/
https://www.ncbi.nlm.nih.gov/pubmed/36074101
http://dx.doi.org/10.1158/1541-7786.MCR-22-0133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716242/
https://www.ncbi.nlm.nih.gov/pubmed/36074101
http://dx.doi.org/10.1158/1541-7786.MCR-22-0133

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