NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition

Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fatality rates in advanced stages due to its chemoresistant properties. LGSOC is characterized by activation of MAPK signaling, and recent clinical trials indicate that the MEK inhibitor (MEKi) trametini...

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Detalles Bibliográficos
Autores principales: Llaurado Fernandez, Marta, Hijmans, E. Marielle, Gennissen, Annemiek M.C., Wong, Nelson K.Y., Li, Shang, Wisman, G. Bea A., Hamilton, Aleksandra, Hoenisch, Joshua, Dawson, Amy, Lee, Cheng-Han, Bittner, Madison, Kim, Hannah, DiMattia, Gabriel E., Lok, Christianne A.R., Lieftink, Cor, Beijersbergen, Roderick L., de Jong, Steven, Carey, Mark S., Bernards, René, Berns, Katrien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Targeting Drug Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716250/
https://www.ncbi.nlm.nih.gov/pubmed/36198031
http://dx.doi.org/10.1158/1535-7163.MCT-22-0004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716250/
https://www.ncbi.nlm.nih.gov/pubmed/36198031
http://dx.doi.org/10.1158/1535-7163.MCT-22-0004

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