The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model

We assessed the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, for anti-mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a neo tumor antigen. Dose response experiments alongside testing different routes of administration identified a safe effective tr...

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Detalles Bibliográficos
Autores principales: Graham, Peter T., Nowak, Anna K., Cornwall, Scott M. J., Larma, Irma, Nelson, Delia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716460/
https://www.ncbi.nlm.nih.gov/pubmed/36466911
http://dx.doi.org/10.3389/fimmu.2022.969678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716460/
https://www.ncbi.nlm.nih.gov/pubmed/36466911
http://dx.doi.org/10.3389/fimmu.2022.969678

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