Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription program through de novo enhancers. By integrative analysis of t...

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Detalles Bibliográficos
Autores principales: Deng, Qu, Natesan, Ramakrishnan, Cidre-Aranaz, Florencia, Arif, Shehbeel, Liu, Ying, Rasool, Reyaz ur, Wang, Pei, Mitchell-Velasquez, Erick, Das, Chandan Kanta, Vinca, Endrit, Cramer, Zvi, Grohar, Patrick J., Chou, Margaret, Kumar-Sinha, Chandan, Weber, Kristy, Eisinger-Mathason, T.S. Karin, Grillet, Nicolas, Grünewald, Thomas, Asangani, Irfan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716578/
https://www.ncbi.nlm.nih.gov/pubmed/35705030
http://dx.doi.org/10.1016/j.celrep.2022.110971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716578/
https://www.ncbi.nlm.nih.gov/pubmed/35705030
http://dx.doi.org/10.1016/j.celrep.2022.110971

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