Receptor editing constrains development of phosphatidyl choline-specific B cells in V(H)12-transgenic mice

B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by V(H)12/Vκ4/5H. Two checkpoints are thought to focus PtC(+) B cell maturation in V(H)12-transgenic mice (VH12 mice): V-J rearrangements encoding a “pe...

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Detalles Bibliográficos
Autores principales: Worth, Alexandra N., Palmer, Victoria L., Schabla, N. Max, Perry, Greg A., Fraser-Philbin, Anna N., Swanson, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716649/
https://www.ncbi.nlm.nih.gov/pubmed/35705027
http://dx.doi.org/10.1016/j.celrep.2022.110899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716649/
https://www.ncbi.nlm.nih.gov/pubmed/35705027
http://dx.doi.org/10.1016/j.celrep.2022.110899

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