HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success

RATIONALE: Previous studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical trial for prevention of peanut allergy, while it was a risk...

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Detalles Bibliográficos
Autores principales: Kanchan, Kanika, Shankar, Gautam, Huffaker, Michelle F., Bahnson, Henry T., Chinthrajah, R Sharon, Sanda, Srinath, Manohar, Monali, Ling, Hua, Paschall, Justin E., Toit, George Du, Ruczinski, Ingo, Togias, Alkis, Lack, Gideon, Nadeau, Kari C., Jones, Stacie M., Nepom, Gerald T., Mathias, Rasika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717393/
https://www.ncbi.nlm.nih.gov/pubmed/36466872
http://dx.doi.org/10.3389/fimmu.2022.941839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717393/
https://www.ncbi.nlm.nih.gov/pubmed/36466872
http://dx.doi.org/10.3389/fimmu.2022.941839

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