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MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis

BACKGROUND: Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application. This study was aimed to explore the potential of microRNAs (miRNAs) as an inhibitor of ODC. METHODS: miRNA array was used to id...

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Detalles Bibliográficos
Autores principales: Liu, Ningning, Zhang, Tianpeng, Steer, Clifford J., Song, Guisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717536/
https://www.ncbi.nlm.nih.gov/pubmed/36457036
http://dx.doi.org/10.1186/s13578-022-00930-3