The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis

OBJECTIVE: This study aims to assess the efficacy of the anticatabolic ‘a disintegrin and metalloproteinase with thrombospondin motif-5’ (ADAMTS-5) inhibitor, S201086/GLPG1972, in slowing cartilage loss in participants with knee osteoarthritis (OA). DESIGN: ROCCELLA (NCT03595618) is a randomized, do...

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Detalles Bibliográficos
Autores principales: Imbert, Olivier, Deckx, Henri, Bernard, Katy, van der Aar, Ellen, Pueyo, Maria, Saeed, Nadeem, Fuerst, Thomas, Wirth, Wolfgang, Conaghan, Philip G., Eckstein, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718074/
https://www.ncbi.nlm.nih.gov/pubmed/36474770
http://dx.doi.org/10.1016/j.ocarto.2021.100209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718074/
https://www.ncbi.nlm.nih.gov/pubmed/36474770
http://dx.doi.org/10.1016/j.ocarto.2021.100209

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