Chondrocytic and pharmacokinetic properties of Phlpp inhibitors

OBJECTIVE: The pleckstrin homology domain leucine-rich repeat protein phosphatases (Phlpp1/2) were recently identified as potential therapeutic targets for cartilage regeneration in osteoarthritic joints. Phlpp inhibitors NSC 117079 and NSC 45586 increase chondrocyte proliferation and matrix product...

Descripción completa

Detalles Bibliográficos
Autores principales: Taylor, E.L., Weaver, S.R., Zars, E.L., Turner, C.A., Buhrow, S.A., Reid, J.M., Bradley, E.W., Westendorf, J.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718091/
https://www.ncbi.nlm.nih.gov/pubmed/36474816
http://dx.doi.org/10.1016/j.ocarto.2021.100190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718091/
https://www.ncbi.nlm.nih.gov/pubmed/36474816
http://dx.doi.org/10.1016/j.ocarto.2021.100190

Ejemplares similares