Chondrocytic and pharmacokinetic properties of Phlpp inhibitors

OBJECTIVE: The pleckstrin homology domain leucine-rich repeat protein phosphatases (Phlpp1/2) were recently identified as potential therapeutic targets for cartilage regeneration in osteoarthritic joints. Phlpp inhibitors NSC 117079 and NSC 45586 increase chondrocyte proliferation and matrix product...

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Detalles Bibliográficos
Autores principales: Taylor, E.L., Weaver, S.R., Zars, E.L., Turner, C.A., Buhrow, S.A., Reid, J.M., Bradley, E.W., Westendorf, J.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718091/
https://www.ncbi.nlm.nih.gov/pubmed/36474816
http://dx.doi.org/10.1016/j.ocarto.2021.100190

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