Cargando…
Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions
The THRA gene, encoding the thyroid hormone nuclear receptor TRα1, is expressed in an increasing gradient at the bottom of intestinal crypts, overlapping with high Wnt and Notch activities. Importantly, THRA is upregulated in colorectal cancers, particularly in the high‐Wnt molecular subtype. The ba...
Autores principales: | Giolito, Maria Virginia, La Rosa, Théo, Farhat, Diana, Bodoirat, Serguei, Guardia, Gabriela D. A., Domon‐Dell, Claire, Galante, Pedro A. F., Freund, Jean‐Noel, Plateroti, Michelina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718118/ https://www.ncbi.nlm.nih.gov/pubmed/36217307 http://dx.doi.org/10.1002/1878-0261.13298 |
Ejemplares similares
-
New Case of Thyroid Hormone Resistance α Caused by a Mutation of THRA/TRα1
por: Sun, Hui, et al.
Publicado: (2019) -
Thyroid Hormone Nuclear Receptor TRα1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer
por: Sirakov, Maria, et al.
Publicado: (2021) -
FRI479 Resistance To Thyroid Hormone Due To Thyroid Hormone Receptor Alpha (THRA) Gene Mutation
por: Omar Abdelkarim, Jumana, et al.
Publicado: (2023) -
Thyroid Hormone Signaling and Function: News from Classical and Emerging Models
por: Sirakov, Maria, et al.
Publicado: (2022) -
Editorial: Targeting Thyroid Hormone-Dependent Pathways in Proliferative and Degenerative Disorders
por: Perra, Andrea, et al.
Publicado: (2022)