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Effect of autotaxin inhibition in a surgically-induced mouse model of osteoarthritis
OBJECTIVE: Osteoarthritis (OA) is a degenerative joint disease with no approved disease modifying therapy. The enzyme autotaxin (ATX) converts lysophoshatidylcholine analogues to lysophosphatidic acid. Systemic inhibition of ATX reduces pain in animal models of OA; however, OA disease-modifying effe...
Autores principales: | Datta, Poulami, Gandhi, Rajiv, Nakamura, Sayaka, Lively, Starlee, Rossomacha, Evgeny, Potla, Pratibha, Shestopaloff, Konstantin, Endisha, Helal, Pastrello, Chiara, Jurisica, Igor, Rockel, Jason S., Kapoor, Mohit |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718142/ https://www.ncbi.nlm.nih.gov/pubmed/36474685 http://dx.doi.org/10.1016/j.ocarto.2020.100080 |
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