Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis

OBJECTIVE: To gain insight into Treg interactions with synovial tissues in early OA, an equine tri-culture model of OA was used to test the hypothesis that Tregs, in the absence of T Helper 17 ​cells, are sufficient to resolve inflammation elicited by IL-1β. METHODS: To model normal and OA joints, s...

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Detalles Bibliográficos
Autores principales: Keller, Laura E., Tait Wojno, Elia D., Begum, Laila, Fortier, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718146/
https://www.ncbi.nlm.nih.gov/pubmed/36474817
http://dx.doi.org/10.1016/j.ocarto.2021.100193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718146/
https://www.ncbi.nlm.nih.gov/pubmed/36474817
http://dx.doi.org/10.1016/j.ocarto.2021.100193

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