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Hyaluronic acid-alendronate conjugate: A macromolecular drug delivery system for intra-articular treatment of osteoarthritis

OBJECTIVE: Osteoarthritis (OA) is a painful degenerative disease of the whole joint structure, including articular cartilage, synovial fluid, and subchondral bone. Hyaluronic acid (HA), an anionic non-sulfated glycosaminoglycan, is commonly used for intra-articular (IA) treatment in OA, while bispho...

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Detalles Bibliográficos
Autores principales: Pluda, Stefano, Beninatto, Riccardo, Soato, Matteo, Barbera, Carlo, di Lucia, Alba, Fassina, Lidia, Gatti, Filippo, Guarise, Cristian, Galesso, Devis, Pavan, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718194/
https://www.ncbi.nlm.nih.gov/pubmed/36474988
http://dx.doi.org/10.1016/j.ocarto.2021.100159