Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors

Hypermutation due to DNA mismatch repair (MMR) deficiencies can accelerate the development of antibiotic resistance in Pseudomonas aeruginosa. Whether hypermutators generate resistance through predominantly similar molecular mechanisms to wild-type (WT) strains is not fully understood. Here, we show...

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Detalles Bibliográficos
Autores principales: Dulanto Chiang, Augusto, Patil, Prashant P., Beka, Lidia, Youn, Jung-Ho, Launay, Adrien, Bonomo, Robert A., Khil, Pavel P., Dekker, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718400/
https://www.ncbi.nlm.nih.gov/pubmed/36399436
http://dx.doi.org/10.1371/journal.pbio.3001878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718400/
https://www.ncbi.nlm.nih.gov/pubmed/36399436
http://dx.doi.org/10.1371/journal.pbio.3001878

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