Cargando…

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcomes remains understudied. Transcriptomic analysis o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wagner, Allison R, Weindel, Chi G, West, Kelsi O, Scott, Haley M, Watson, Robert O, Patrick, Kristin L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718523/ https://www.ncbi.nlm.nih.gov/pubmed/36409059 http://dx.doi.org/10.7554/eLife.82244

Ejemplares similares

Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
por: Meinke, Stefan, et al.
Publicado: (2020)

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program
por: Ratnadiwakara, Madara, et al.
Publicado: (2018)

Striking circadian neuron diversity and cycling of Drosophila alternative splicing
por: Wang, Qingqing, et al.
Publicado: (2018)

Alternative splicing of apoptosis genes promotes human T cell survival
por: Blake, Davia, et al.
Publicado: (2022)

Viral-induced alternative splicing of host genes promotes influenza replication
por: Thompson, Matthew G, et al.
Publicado: (2020)

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer
por: Munkley, Jennifer, et al.
Publicado: (2019)

Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
por: Benegas, Gonzalo, et al.
Publicado: (2022)

Correction: The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
por: Li, Qin, et al.
Publicado: (2017)

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
por: Stagsted, Lotte Victoria Winther, et al.
Publicado: (2021)

Coverage-dependent bias creates the appearance of binary splicing in single cells
por: Buen Abad Najar, Carlos F, et al.
Publicado: (2020)

SAM homeostasis is regulated by CFI(m)-mediated splicing of MAT2A
por: Scarborough, Anna M, et al.
Publicado: (2021)

RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit
por: Milligan, Laura, et al.
Publicado: (2017)

An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning
por: Ehrmann, Ingrid, et al.
Publicado: (2019)

Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response
por: Cherry, Patrick D, et al.
Publicado: (2019)

Genome plasticity in Candida albicans is driven by long repeat sequences
por: Todd, Robert T, et al.
Publicado: (2019)

Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers
por: Nakagaki-Silva, Erick E, et al.
Publicado: (2019)

Transitions in cell potency during early mouse development are driven by Notch
por: Menchero, Sergio, et al.
Publicado: (2019)

m(6)A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site
por: Parker, Matthew T, et al.
Publicado: (2022)

Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages
por: Sacta, Maria A, et al.
Publicado: (2018)

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
por: Li, Qin, et al.
Publicado: (2014)

A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway
por: Herron, R Samuel, et al.
Publicado: (2023)

The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation
por: Arbona, Jean-Michel, et al.
Publicado: (2018)

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells
por: Purshouse, Karin, et al.
Publicado: (2022)

IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP
por: Roy, Arunava, et al.
Publicado: (2019)

The transcriptional elongation rate regulates alternative polyadenylation in yeast
por: Geisberg, Joseph V, et al.
Publicado: (2020)

ZC3H4 restricts non-coding transcription in human cells
por: Estell, Chris, et al.
Publicado: (2021)

Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics
por: Ramesh, Vijyendra, et al.
Publicado: (2023)

Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria
por: Quin, Jaclyn E, et al.
Publicado: (2017)

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
por: McClure, Allison W, et al.
Publicado: (2021)

Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast
por: Turner, Rachael Emily, et al.
Publicado: (2021)

3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
por: Himadewi, Pamela, et al.
Publicado: (2021)

Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals
por: Sanford, Eric M, et al.
Publicado: (2020)

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability
por: Felletti, Michele, et al.
Publicado: (2021)

Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development
por: Zhou, Li, et al.
Publicado: (2018)

Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing
por: Gorbea, Carlos, et al.
Publicado: (2019)

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis
por: West, Alan MV, et al.
Publicado: (2019)

Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster
por: Choudhury, Subhendu Roy, et al.
Publicado: (2016)

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes
por: Touray, Abdoulie O, et al.
Publicado: (2023)

Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo
por: Etheridge, Thomas J, et al.
Publicado: (2021)

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
por: Sanborn, Adrian L, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hj61hgnsiq35594tuh47d4frjp