Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general a...

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Detalles Bibliográficos
Autores principales: Proj, Matic, Hrast, Martina, Bajc, Gregor, Frlan, Rok, Meden, Anže, Butala, Matej, Gobec, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718554/
https://www.ncbi.nlm.nih.gov/pubmed/36446617
http://dx.doi.org/10.1080/14756366.2022.2149745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718554/
https://www.ncbi.nlm.nih.gov/pubmed/36446617
http://dx.doi.org/10.1080/14756366.2022.2149745

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