Seed-induced Aβ deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) which ultimately forms plaques. These Aβ deposits can be induced in APP transgenic mouse models by prion-like seeding. It has been widely accepted that anosmia and hyposmia occur during the early stages of AD, even befor...

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Detalles Bibliográficos
Autores principales: Ziegler-Waldkirch, Stephanie, Friesen, Marina, Loreth, Desirée, Sauer, Jonas-Frederic, Kemna, Solveig, Hilse, Alexandra, Erny, Daniel, Helm, Christina, d´Errico, Paolo, Prinz, Marco, Bartos, Marlene, Meyer-Luehmann, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718674/
https://www.ncbi.nlm.nih.gov/pubmed/35869271
http://dx.doi.org/10.1038/s41380-022-01686-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718674/
https://www.ncbi.nlm.nih.gov/pubmed/35869271
http://dx.doi.org/10.1038/s41380-022-01686-5

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