Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders

Glutamate carboxypeptidase-II (GCPII) expression in brain is increased by inflammation, e.g. by COVID19 infection, where it reduces NAAG stimulation of metabotropic glutamate receptor type 3 (mGluR3). GCPII-mGluR3 signaling is increasingly linked to higher cognition, as genetic alterations that weak...

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Detalles Bibliográficos
Autores principales: Yang, Shengtao, Datta, Dibyadeep, Elizabeth Woo, Duque, Alvaro, Morozov, Yury M., Arellano, Jon, Slusher, Barbara S., Wang, Min, Arnsten, Amy F. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718677/
https://www.ncbi.nlm.nih.gov/pubmed/35732693
http://dx.doi.org/10.1038/s41380-022-01656-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718677/
https://www.ncbi.nlm.nih.gov/pubmed/35732693
http://dx.doi.org/10.1038/s41380-022-01656-x

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