DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B

DNA methylation is a key epigenetic modification to regulate gene expression in mammalian cells. Abnormal DNA methylation in gene promoters is common across human cancer types. DNMT3B is the main de novo methyltransferase enhanced in several primary tumors. How de novo methylation is established in...

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Detalles Bibliográficos
Autores principales: Loaeza-Loaeza, Jaqueline, Cerecedo-Castillo, Angel Josué, Rodríguez-Ruiz, Hugo Alberto, Castro-Coronel, Yaneth, Del Moral-Hernández, Oscar, Recillas-Targa, Félix, Hernández-Sotelo, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718745/
https://www.ncbi.nlm.nih.gov/pubmed/36460706
http://dx.doi.org/10.1038/s41598-022-24186-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718745/
https://www.ncbi.nlm.nih.gov/pubmed/36460706
http://dx.doi.org/10.1038/s41598-022-24186-6

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