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Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors

Complex carbohydrates (glycans) are major players in all organisms due to their structural, energy, and communication roles. This last essential role involves interacting and/or signaling through a plethora of glycan-binding proteins. The design and synthesis of glycans as potential drug candidates...

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Detalles Bibliográficos
Autores principales: He, Peng, Zhang, Xing, Xia, Ke, Green, Dixy E., Baytas, Sultan, Xu, Yongmei, Pham, Truong, Liu, Jian, Zhang, Fuming, Almond, Andrew, Linhardt, Robert J., DeAngelis, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718760/
https://www.ncbi.nlm.nih.gov/pubmed/36460670
http://dx.doi.org/10.1038/s41467-022-34788-3