The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication

Control of RNA Polymerase II (pol II) elongation is a critical component of gene expression in mammalian cells. The PNUTS-PP1 complex controls elongation rates, slowing pol II after polyadenylation sites to promote termination. The Kaposi’s sarcoma-associated herpesvirus (KSHV) co-opts pol II to exp...

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Detalles Bibliográficos
Autores principales: Devlin, Anne M., Shukla, Ashutosh, Ruiz, Julio C., Barnes, Spencer D., Govindan, Ashwin, Hunter, Olga V., Scarborough, Anna M., D’Orso, Iván, Conrad, Nicholas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718767/
https://www.ncbi.nlm.nih.gov/pubmed/36460671
http://dx.doi.org/10.1038/s41467-022-35268-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718767/
https://www.ncbi.nlm.nih.gov/pubmed/36460671
http://dx.doi.org/10.1038/s41467-022-35268-4

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