Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

Recent studies have shown that G protein coupled receptors (GPCRs) show selective and promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the range of coupling preferences remain unclear. Here, we use Molecular Dynamics (MD) simulations on ten GPCR:G protein complexes...

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Detalles Bibliográficos
Autores principales: Sandhu, Manbir, Cho, Aaron, Ma, Ning, Mukhaleva, Elizaveta, Namkung, Yoon, Lee, Sangbae, Ghosh, Soumadwip, Lee, John H., Gloriam, David E., Laporte, Stéphane A., Babu, M. Madan, Vaidehi, Nagarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718833/
https://www.ncbi.nlm.nih.gov/pubmed/36460632
http://dx.doi.org/10.1038/s41467-022-34055-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718833/
https://www.ncbi.nlm.nih.gov/pubmed/36460632
http://dx.doi.org/10.1038/s41467-022-34055-5

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