TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage

Intracellular Ca(2+) dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca(2+) regulatory modules cannot successfully abolish this symptom. Here we show that the knockout of transient receptor potential canonical (TRPC) channel isoforms TRPC1 and TRPC6 ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Na, Tian, Wen, Ma, Guang-Yuan, Xiao, Xiong, Zhou, Lei, Li, Ze-Zhi, Liu, Xiao-Xiao, Li, Chong-Yao, Wu, Ke-Han, Liu, Wenjuan, Wang, Xue-Ying, Gao, Yuan-Yuan, Yang, Xin, Qi, Jianzhao, Li, Ding, Liu, Yang, Chen, Wen-Sheng, Gao, Jinming, Li, Xiao-Qiang, Cao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718841/
https://www.ncbi.nlm.nih.gov/pubmed/36460692
http://dx.doi.org/10.1038/s41467-022-35242-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718841/
https://www.ncbi.nlm.nih.gov/pubmed/36460692
http://dx.doi.org/10.1038/s41467-022-35242-0

Ejemplares similares