TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage

Intracellular Ca(2+) dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca(2+) regulatory modules cannot successfully abolish this symptom. Here we show that the knockout of transient receptor potential canonical (TRPC) channel isoforms TRPC1 and TRPC6 ca...

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Detalles Bibliográficos
Autores principales: Tang, Na, Tian, Wen, Ma, Guang-Yuan, Xiao, Xiong, Zhou, Lei, Li, Ze-Zhi, Liu, Xiao-Xiao, Li, Chong-Yao, Wu, Ke-Han, Liu, Wenjuan, Wang, Xue-Ying, Gao, Yuan-Yuan, Yang, Xin, Qi, Jianzhao, Li, Ding, Liu, Yang, Chen, Wen-Sheng, Gao, Jinming, Li, Xiao-Qiang, Cao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718841/
https://www.ncbi.nlm.nih.gov/pubmed/36460692
http://dx.doi.org/10.1038/s41467-022-35242-0

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