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Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish
The glucagon receptor (GCGR) is a potential target for diabetes therapy. Several emerging GCGR antagonism-based therapies are under preclinical and clinical development. However, GCGR antagonism, as well as genetically engineered GCGR deficiency in animal models, are accompanied by α-cell hyperplasi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719020/ https://www.ncbi.nlm.nih.gov/pubmed/36334626 http://dx.doi.org/10.1016/j.jbc.2022.102665 |