Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells

INTRODUCTION: Human induced pluripotent stem cells (hiPSCs) are useful tools for reproducing neural development in vitro. However, each hiPSC line has a different ability to differentiate into specific lineages, known as differentiation propensity, resulting in reduced reproducibility and increased...

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Detalles Bibliográficos
Autores principales: Sekiya, Asato, Takasawa, Ken, Arai, Yoshikazu, Horike, Shin-ichi, Akutsu, Hidenori, Umezawa, Akihiro, Nishino, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719094/
https://www.ncbi.nlm.nih.gov/pubmed/36514370
http://dx.doi.org/10.1016/j.reth.2022.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719094/
https://www.ncbi.nlm.nih.gov/pubmed/36514370
http://dx.doi.org/10.1016/j.reth.2022.11.007

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