Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis

BACKGROUND: Osteoarthritis (OA) is the most common chronic disease. It is characterized by high levels of clinical heterogeneity and low inflammation. Therefore, elucidation of the mechanisms that regulate gene expression is critical for developing effective OA therapies. This study aimed to explore...

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Detalles Bibliográficos
Autores principales: Chen, Yang, Liu, Yiheng, Jiang, Kai, Wen, Zi, Cao, Xu, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719095/
https://www.ncbi.nlm.nih.gov/pubmed/36514784
http://dx.doi.org/10.1016/j.jot.2022.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719095/
https://www.ncbi.nlm.nih.gov/pubmed/36514784
http://dx.doi.org/10.1016/j.jot.2022.11.002

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