Plumbagin rescues the granulosa cell’s pyroptosis by reducing WTAP-mediated N6-methylation in polycystic ovary syndrome

The survival of ovary granulosa cells (GC) is critical in the initiation and progression of polycystic ovary syndrome (PCOS) in females. Here, we found that the PCOS process is accompanied by massive GC pyroptosis resulting from Caspase-1 inflammasome activation. Administration of plumbagin, an effe...

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Detalles Bibliográficos
Autores principales: Cai, Zhaowei, He, Shaojuan, Liu, Rongju, Zhou, Liling, Zhao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719148/
https://www.ncbi.nlm.nih.gov/pubmed/36463191
http://dx.doi.org/10.1186/s13048-022-01058-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719148/
https://www.ncbi.nlm.nih.gov/pubmed/36463191
http://dx.doi.org/10.1186/s13048-022-01058-1

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