Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cells

The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response. ISR activation was reported in neurological disorders and solid tumors; however, the function of ISR and its role as a possible therapeutic target in hematological m...

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Detalles Bibliográficos
Autores principales: Dudka, Wioleta, Hoser, Grazyna, Mondal, Shamba S., Turos-Korgul, Laura, Swatler, Julian, Kusio-Kobialka, Monika, Wołczyk, Magdalena, Klejman, Agata, Brewinska-Olchowik, Marta, Kominek, Agata, Wiech, Milena, Machnicki, Marcin M., Seferynska, Ilona, Stoklosa, Tomasz, Piwocka, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719211/
https://www.ncbi.nlm.nih.gov/pubmed/36460969
http://dx.doi.org/10.1186/s12885-022-10289-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719211/
https://www.ncbi.nlm.nih.gov/pubmed/36460969
http://dx.doi.org/10.1186/s12885-022-10289-w

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