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Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma
BACKGROUND: Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains unclear how the heterogeneous physical microenvironment affects stemness expressi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719217/ https://www.ncbi.nlm.nih.gov/pubmed/36463272 http://dx.doi.org/10.1186/s12967-022-03778-w |