CBMS-5 STEAROYL-COA DESATURASE INHIBITOR INDUCES APOPTOSIS VIA ENHANCING LIPOLYSIS IN IDH MUTANT GLIOMA

BACKGROUND: Little is known about the antineoplastic effect and the mechanism of Stearoyl-CoA desaturase (SCD) inhibitor which catalyzes the biosynthesis of monounsaturated fatty acids (MUFA). Mutant isocitrate dehydrogenase (IDH) catalyzes the NADPH-mediated reduction of α-ketoglutarate (αKG) to 2-...

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Detalles Bibliográficos
Autores principales: Zhang, Lumin, Dowdy, Tyrone, Lita, Adrian, Suzuki, Ryoichi, Kida, Satoru, Ooishi, Tomoya, Koizumi, Shinichiro, Kurozumi, Kazuhiko, Larion, Mioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719313/
http://dx.doi.org/10.1093/noajnl/vdac167.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719313/
http://dx.doi.org/10.1093/noajnl/vdac167.004

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