ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

Growth factor-induced, ERK-mediated induction of immediate-early genes (IEGs) is crucial for cell growth and tumorigenesis. Although IEG expression is mainly regulated at the level of transcription elongation by RNA polymerase-II (Pol-II) promoter-proximal pausing and its release, the role of ERK in...

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Detalles Bibliográficos
Autores principales: Ohe, Seina, Kubota, Yuji, Yamaguchi, Kiyoshi, Takagi, Yusuke, Nashimoto, Junichiro, Kozuka-Hata, Hiroko, Oyama, Masaaki, Furukawa, Yoichi, Takekawa, Mutsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719515/
https://www.ncbi.nlm.nih.gov/pubmed/36463234
http://dx.doi.org/10.1038/s41467-022-35230-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719515/
https://www.ncbi.nlm.nih.gov/pubmed/36463234
http://dx.doi.org/10.1038/s41467-022-35230-4

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