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Design of MMP-1 inhibitors via SAR transfer and experimental validation
New matrix metalloproteinase 1 (MMP-1) inhibitors were predicted using the structure–activity relationship (SAR) transfer method based on a series of analogues of kinesin-like protein 11 (KIF11) inhibitors. Compounds 5–7 predicted to be highly potent against MMP-1 were synthesized and tested for MMP...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719525/ https://www.ncbi.nlm.nih.gov/pubmed/36463250 http://dx.doi.org/10.1038/s41598-022-25079-4 |