Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while GIPR neutralizing antibodies produce additive weigh...

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Detalles Bibliográficos
Autores principales: Yang, Bin, Gelfanov, Vasily M., El, Kimberley, Chen, Alex, Rohlfs, Rebecca, DuBois, Barent, Kruse Hansen, Ann Maria, Perez-Tilve, Diego, Knerr, Patrick J., D'Alessio, David, Campbell, Jonathan E., Douros, Jonathan D., Finan, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719863/
https://www.ncbi.nlm.nih.gov/pubmed/36400403
http://dx.doi.org/10.1016/j.molmet.2022.101638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719863/
https://www.ncbi.nlm.nih.gov/pubmed/36400403
http://dx.doi.org/10.1016/j.molmet.2022.101638

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