A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides

Cell penetrating peptides (CPPs) are a promising technology for therapeutic delivery of macromolecular cargos. CPPs have generally used covalent linkages to cargo, ensuring a common fate as one molecule. Conversely, our CPP-adaptor, TAT-CaM, noncovalently binds calmodulin binding sequence (CBS)-cont...

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Detalles Bibliográficos
Autores principales: Morris, Daniel P., Snipes, Lucy C., Hill, Stephanie A., Woods, Michael M., Mbugua, Maria M., Wade, Lydia R., McMurry, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720253/
https://www.ncbi.nlm.nih.gov/pubmed/36479201
http://dx.doi.org/10.3389/fphar.2022.1070464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720253/
https://www.ncbi.nlm.nih.gov/pubmed/36479201
http://dx.doi.org/10.3389/fphar.2022.1070464

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