Suppression of amyloid-β fibril growth by drug-engineered polymorph transformation

Fibrillization of the protein amyloid β is assumed to trigger Alzheimer’s pathology. Approaches that target amyloid plaques, however, have garnered limited clinical success, and their failures may relate to the scarce understanding of the impact of potential drugs on the intertwined stages of fibril...

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Detalles Bibliográficos
Autores principales: Mafimoghaddam, Sima, Xu, Yuechuan, Sherman, Michael B., Orlova, Elena V., Karki, Prashant, Orman, Mehmet A., Vekilov, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720346/
https://www.ncbi.nlm.nih.gov/pubmed/36334629
http://dx.doi.org/10.1016/j.jbc.2022.102662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720346/
https://www.ncbi.nlm.nih.gov/pubmed/36334629
http://dx.doi.org/10.1016/j.jbc.2022.102662

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