Autoreactivity and broad neutralization of antibodies against HIV-1 are governed by distinct mutations: Implications for vaccine design strategies

Many of the best HIV-1 broadly neutralizing antibodies (bnAbs) known have poly-/autoreactive features that disfavor normal B cell development and maturation, posing a major hurdle in developing an effective HIV-1 vaccine. Key to resolving this problem is to understand if, and to what extent, neutral...

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Detalles Bibliográficos
Autores principales: Li, Xiaojun, Liao, Dongmei, Li, Zhengyang, Li, Jixi, Diaz, Marilyn, Verkoczy, Laurent, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720396/
https://www.ncbi.nlm.nih.gov/pubmed/36479128
http://dx.doi.org/10.3389/fimmu.2022.977630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720396/
https://www.ncbi.nlm.nih.gov/pubmed/36479128
http://dx.doi.org/10.3389/fimmu.2022.977630

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