Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

PARP13/ZAP (zinc-finger antiviral protein) acts against multiple viruses by promoting degradation of viral mRNA. PARP13 has four N-terminal zinc (Zn) fingers that bind CG-rich nucleotide sequences, a C-terminal ADP ribosyltransferase fold, and a central region with a fifth Zn finger and tandem WWE d...

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Detalles Bibliográficos
Autores principales: Kuttiyatveetil, Jijin R.A., Soufari, Heddy, Dasovich, Morgan, Uribe, Isabel R., Mirhasan, Manija, Cheng, Shang-Jung, Leung, Anthony K.L., Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720839/
https://www.ncbi.nlm.nih.gov/pubmed/36288691
http://dx.doi.org/10.1016/j.celrep.2022.111529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720839/
https://www.ncbi.nlm.nih.gov/pubmed/36288691
http://dx.doi.org/10.1016/j.celrep.2022.111529

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