Prediction of polyreactive and nonspecific single-chain fragment variables through structural biochemical features and protein language-based descriptors

BACKGROUND: Monoclonal antibodies (mAbs) have been used as therapeutic agents, which must overcome many developability issues after the discovery from in vitro display libraries. Especially, polyreactive mAbs can strongly bind to a specific target and weakly bind to off-target proteins, which leads...

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Detalles Bibliográficos
Autores principales: Lim, Hocheol, No, Kyoung Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720949/
https://www.ncbi.nlm.nih.gov/pubmed/36471239
http://dx.doi.org/10.1186/s12859-022-05010-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720949/
https://www.ncbi.nlm.nih.gov/pubmed/36471239
http://dx.doi.org/10.1186/s12859-022-05010-4

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