Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis

BACKGROUND: The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure remains unclear. RESULTS: Here we discovered that Piezo1, a mechanosensitive ion c...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoqiang, Zeng, Honghui, Wang, Le, Luo, Siweier, Zhou, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720979/
https://www.ncbi.nlm.nih.gov/pubmed/36471394
http://dx.doi.org/10.1186/s13578-022-00931-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720979/
https://www.ncbi.nlm.nih.gov/pubmed/36471394
http://dx.doi.org/10.1186/s13578-022-00931-2

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