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Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis
BACKGROUND: The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure remains unclear. RESULTS: Here we discovered that Piezo1, a mechanosensitive ion c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720979/ https://www.ncbi.nlm.nih.gov/pubmed/36471394 http://dx.doi.org/10.1186/s13578-022-00931-2 |