Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells using angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP-1) as the primary receptor and entry co-factor, respectively. Cell entry is the first and major step in initiation of the viral life cycle, representing an ide...

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Detalles Bibliográficos
Autores principales: Hashizume, Mei, Takashima, Ayako, Ono, Chikako, Okamoto, Toru, Iwasaki, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721373/
https://www.ncbi.nlm.nih.gov/pubmed/36481388
http://dx.doi.org/10.1016/j.antiviral.2022.105481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721373/
https://www.ncbi.nlm.nih.gov/pubmed/36481388
http://dx.doi.org/10.1016/j.antiviral.2022.105481

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