Genome-edited zebrafish model of ABCC8 loss-of-function disease

ATP-sensitive potassium channel (K(ATP))gain- (GOF) and loss-of-function (LOF) mutations underlie human neonatal diabetes mellitus (NDM) and hyperinsulinism (HI), respectively. While transgenic mice expressing incomplete K(ATP) LOF do reiterate mild hyperinsulinism, K(ATP) knockout animals do not ex...

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Detalles Bibliográficos
Autores principales: Ikle, Jennifer M., Tryon, Robert C., Singareddy, Soma S., York, Nathaniel W., Remedi, Maria S., Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721409/
https://www.ncbi.nlm.nih.gov/pubmed/36458573
http://dx.doi.org/10.1080/19382014.2022.2149206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721409/
https://www.ncbi.nlm.nih.gov/pubmed/36458573
http://dx.doi.org/10.1080/19382014.2022.2149206

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