Cargando…

Genome-edited zebrafish model of ABCC8 loss-of-function disease

ATP-sensitive potassium channel (K(ATP))gain- (GOF) and loss-of-function (LOF) mutations underlie human neonatal diabetes mellitus (NDM) and hyperinsulinism (HI), respectively. While transgenic mice expressing incomplete K(ATP) LOF do reiterate mild hyperinsulinism, K(ATP) knockout animals do not ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ikle, Jennifer M., Tryon, Robert C., Singareddy, Soma S., York, Nathaniel W., Remedi, Maria S., Nichols, Colin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721409/ https://www.ncbi.nlm.nih.gov/pubmed/36458573 http://dx.doi.org/10.1080/19382014.2022.2149206

Ejemplares similares

SAT-166 Techniques For Direct Imaging Of Beta-cell Activity And Glucose Homeostasis In Zebrafish
por: Ikle, Jennifer, et al.
Publicado: (2019)

Beta‐cell excitability and excitability‐driven diabetes in adult Zebrafish islets
por: Emfinger, Christopher H., et al.
Publicado: (2019)

ABCC9-related Intellectual disability Myopathy Syndrome is a K(ATP) channelopathy with loss-of-function mutations in ABCC9
por: Smeland, Marie F., et al.
Publicado: (2019)

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes
por: Baier, Leslie J., et al.
Publicado: (2015)

The role of membrane excitability in pancreatic β-cell glucotoxicity
por: Shyr, Zeenat A., et al.
Publicado: (2019)

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells
por: Emfinger, Christopher H., et al.
Publicado: (2017)

Characterization of Zebrafish Abcc4 as an Efflux Transporter of Organochlorine Pesticides
por: Lu, Xing, et al.
Publicado: (2014)

Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead
por: Lu, Xing, et al.
Publicado: (2021)

In vivo monitoring of intracellular Ca(2+) dynamics in the pancreatic β-cells of zebrafish embryos
por: Lorincz, Reka, et al.
Publicado: (2018)

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the K(ATP) channel
por: Remedi, Maria S., et al.
Publicado: (2017)

Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis
por: Sun, Jianjian, et al.
Publicado: (2020)

Neonatal Hypoglycaemia due to ABCC8 Gene Mutation
por: Kumar, Ashok, et al.
Publicado: (2020)

First Report of Diabetes Phenotype due to a Loss-of-Function ABCC8 Mutation Previously Known to Cause Congenital Hyperinsulinism
por: Koufakis, Theocharis, et al.
Publicado: (2019)

Chronic Antidiabetic Sulfonylureas In Vivo: Reversible Effects on Mouse Pancreatic β-Cells
por: Remedi, Maria Sara, et al.
Publicado: (2008)

Case Report: Loss-of-Function ABCC9 Genetic Variant Associated With Ventricular Fibrillation
por: Zaytseva, Anastasia, et al.
Publicado: (2022)

Differential mechanisms of Cantú syndrome–associated gain of function mutations in the ABCC9 (SUR2) subunit of the K(ATP) channel
por: Cooper, Paige E., et al.
Publicado: (2015)

Correspondence to ‘Neonatal hypoglycaemia due to ABCC8 gene mutation’
por: Maralihalli, Mahesh
Publicado: (2021)

Case report: Congenital hyperinsulinemia with ABCC8 gene mutations
por: Zhang, Jin, et al.
Publicado: (2022)

Neonatal hyperinsulinism with an ABCC8 mutation: A case report
por: Liu, Meng-Tong, et al.
Publicado: (2023)

Promoter DNA Methylation Regulates Murine SUR1 (Abcc8) and SUR2 (Abcc9) Expression in HL-1 Cardiomyocytes
por: Fatima, Naheed, et al.
Publicado: (2012)

Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish
por: Guo, Shuyu, et al.
Publicado: (2022)

Integration of genomic analysis and transcript expression of ABCC8 and KCNJ11 in focal form of congenital hyperinsulinism
por: Wieland, Ilse, et al.
Publicado: (2022)

Paternally inherited ABCC8 mutation causing diffuse congenital hyperinsulinism
por: Chandran, Suresh, et al.
Publicado: (2013)

Diazoxide-unresponsive congenital hyperinsulinism associated with ABCC8 nonsense mutation
por: Hussain, Suhaimi, et al.
Publicado: (2015)

The Abcc6a Knockout Zebrafish Model as a Novel Tool for Drug Screening for Pseudoxanthoma Elasticum
por: Van Gils, M., et al.
Publicado: (2022)

Utilising polymorphisms to achieve allele-specific genome editing in zebrafish
por: Capon, Samuel J., et al.
Publicado: (2016)

Precise A•T to G•C base editing in the zebrafish genome
por: Qin, Wei, et al.
Publicado: (2018)

PCR artifact in testing for homologous recombination in genomic editing in zebrafish
por: Won, Minho, et al.
Publicado: (2017)

Fishing for answers to hemostatic and thrombotic disease: Genome editing in zebrafish
por: Raghunath, Azhwar, et al.
Publicado: (2022)

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
por: Hill, Christopher R., et al.
Publicado: (2013)

Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines
por: Low, Floren G., et al.
Publicado: (2020)

Dominantly acting ABCC8 mutations in patients with medically unresponsive hyperinsulinaemic hypoglycaemia
por: Flanagan, SE, et al.
Publicado: (2011)

Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations
por: Riveline, Jean-Pierre, et al.
Publicado: (2012)

Congenital hyperinsulinism: 2 case reports with different rare variants in ABCC8
por: Mouron-Hryciuk, Julie, et al.
Publicado: (2021)

Genotyping of ABCC8, KCNJ11, and HADH in Iranian Infants with Congenital Hyperinsulinism
por: Hashemian, Somayyeh, et al.
Publicado: (2021)

Glucocorticoid-Induced Hyperinsulinism in a Preterm Neonate with Inherited ABCC8 Variant
por: Motte-Signoret, Emmanuelle, et al.
Publicado: (2022)

Lineage Relationship of Direct-Developing Melanocytes and Melanocyte Stem Cells in the Zebrafish
por: Tryon, Robert C., et al.
Publicado: (2011)

ABCC9 Is Downregulated and Prone to Microsatellite Instability on ABCC9tetra in Canine Breast Cancer
por: Hao, Pan, et al.
Publicado: (2022)

Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos
por: Chang, Nannan, et al.
Publicado: (2013)

Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos
por: Aksoy, Yagiz A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tben6q71v6esuvkqrncampe2e4