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DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD). To inhibit ODC, α-difluoromethylornithine (DFMO), an irreversible ODC inhibitor, has been widely used. However, due to its poor pharmacok...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721421/ https://www.ncbi.nlm.nih.gov/pubmed/36451618 http://dx.doi.org/10.1080/14756366.2022.2150186 |