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DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening

Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD). To inhibit ODC, α-difluoromethylornithine (DFMO), an irreversible ODC inhibitor, has been widely used. However, due to its poor pharmacok...

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Detalles Bibliográficos
Autores principales:	Park, Mingu Gordon, Kim, Suyeon Yellena, Lee, C. Justin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721421/ https://www.ncbi.nlm.nih.gov/pubmed/36451618 http://dx.doi.org/10.1080/14756366.2022.2150186

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